Case Control Study - 961 Words

Discussion In recent years, it has been suggested that miRNAs act as key regulators of gene expression networks. Like other genes, single nucleotide polymorphism in miRNA genes can affects their function at different levels, such as miRNA transcription, maturation and target specificity. Our study is the first report of mir 23a, mir155 and mir 196a2 polymorphism in the iranian MS patients. In this case control study we examined the impact of functional mir 155 rs767649, mir196a2 rs11614913 and miR-23a rs3745453 polymorphism on MS risk in a sample of Isfahan population. We found that miR-23a rs3745453 CT variant seem to increase the risk of MS in this population (OR =2.5). Compared with ridolfi et al. The results did not support an†¦show more content†¦Saumet et al. in 2008 observed that miR-23a~27a~24-2 is directly repressed by the PML-RARA oncogene. also in some study upregulation of miR-23a has been observed in cancers(22). Considerable up-regulation of miR-23a was reported by Meng and Gottardo in human bladder cancer and in malignant cholangiocytes compared to normal tissues. Furthermore, Mi et al. in their study showed that miR-23a was among several other miRNAs that have been differentially expressed between acute myeloid leukemia (AMLs) and acute lymphoblastic leukemia (ALLs). In addition, up-regulation of miR-23a/b along with miR-24 has also been identified in osteoblast cell line (20,21). An exonic MiR-155 with rs767649 (T/A) polymorphism in the upstream region of the pre-miR-155 gene is transcribed from the B-cell integration cluster (BIC) that is located on chromosome 21. It has been suggested that miR155 modulate host antiviral immune response by elevating type I IFN signaling. In some study This miRNA proposed to be involved in diverse biological processes, such as inflammation, differentiation, and immunity. Furthermore, dysregulation of miR-155 has been reported in viral infections and different cancers. Some study reported mir155 highly expressed in activated T and B cells as well as macrophage and dendritic cells(23). Our result suggested that rs767649 TT genotype have potential to act as a risk factor for MS(OR=2.5), also 94 % ofShow MoreRelatedFatty Acid Composition Of Adipose Tissue And Colorectal Cancer : A Case Control Study845 Words   |  4 PagesFatty acid composition of adipose tissue and colorectal cancer: a case-control study Colorectal cancer is considered as the third most common cancers worldwide that usually leads to the death of the patient. Studies have proved that lifestyle factors great influence the development and spread of cancer. Modifying the lifestyle can reduce the risk of getting colorectal cancer by 70%. It is noted that more consumption of red and processed meat increase the risk of developing colorectal cancer. 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